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Showing posts with label Vitamin D. Show all posts
Showing posts with label Vitamin D. Show all posts

Tuesday, March 2, 2010

The Not Quite Incredible Shrinking Woman

Speaking of weight, I'm surprised and cautiously optimistic about my recent slow but steady weight loss! I'm almost afraid to mention it in case I jinx it!

While I lost weight with some of my chemo drugs (FEC, to be specific), I gained weight on the other (taxotere). Overall, I gained 10 to 15 pounds during the course of my cancer treatments ... caused by a combination of chemo, steroids, inactivity. Fifteen pounds is considered the average weight gain one might expect during cancer treatments. Now that cancer treatments are over, I have the responsibility for losing what I gained. Oh joy! It's important for many reasons to maintain a healthy body weight. Women who maintain a healthy body weight are less likely to have their cancers recur. That's one of several incentives.

I have been struggling against weight gain for the past 7 years. It just slowly started creeping up on me after never having had to worry about it before. I've never had any particular problems with overeating or eating too much high-calorie junk. When I made concerted efforts to lose weight, I found it very hard. I could muster the will power and stick to it for a good, long time but even then, I could only lose a little weight and then I would plateau and it seemed like no matter what I did, I couldn't lose any more. This was one of the reasons I was seeing my doctor at the time I was diagnosed with breast cancer. He told me to "get more exercise", which was frustrating to hear and I knew that wasn't the complete answer.

Since having breast cancer and learning a little more about hormones, I've learned that weight gain and a drop in metabolism can be symptoms of estrogen dominance. That explains some of the problem if not all of the problem. I learned about estrogen dominance when I was researching my breast cancer, after getting the pathology report that indicated that my tumour was very high in estrogen and low in progesterone. In other words, I had an estrogen-fed tumour and had too much estrogen in my system, which is why I will now take estrogen blockers for the next 5 or more years. Read this short article about estrogen dominance and weight and how balancing your estrogen can not only help you manage your weight, it might also save your life (from breast cancer ); something I wish I had known a few years ago. If I had, I might not have developed breast cancer at all. I should also say that estrogen dominance isn't typically recognized by mainstream medicine and is more in the realm of the naturopathic doctors. I haven't met any mainstream doctors that give a hoot about balancing hormones, except for cutting my estrogen AFTER breast cancer, but from the personal experience of being a woman, I know hormones figure into almost everything. I do believe it's a fine balance. I believe that recognizing and treating estrogen dominance in the first place can prevent some breast cancers.

Since there's no turning back the clock to "prevention", here I am in treatment and doing what I have to do to live. Maybe someone out there will see themselves in my symptoms prior to breast cancer and perhaps prevent themselves from getting breast cancer. That would make me very happy.

Back to weighty things ... I was dismayed to learn that the drug I'm to take for the next 5 years (tamoxifen) can cause weight gain in much the same way that birth control pills can. It felt like just another kick in the boob. But so far that hasn't been the case for me. Not yet anyway. In fact, I've been slowly and steadily losing weight, which is making me SO happy! I can hardly believe it! I've lost at least 5 pounds in the past two or three weeks. And I'm not even trying! That's the surprising part! Previously I would have gained weight drinking water and eating celery! This is too good to be true! I haven't been cutting out breads ... or mayo ... or cheese ... or butter on my potatoes ... or chips and dip on special occasions (such as Olympic hockey games) ... What's going on?! How can this be?

I have no explanation. Maybe if I understood more about estrogen and my other hormones but from what I'm reading, even though estrogen dominance can cause weight gain, so can decreasing estrogen (as happens during menopause, which is where cancer treatments have put me). I find all the hormone information just too difficult to understand. It seems very complex.

Here's a possible theory for my new ability to lost weight. Vitamin D. Was I previously unable to lose weight because I was Vitamin D deficient? Read this article that links increased Vitamin D levels to weight loss. Could it be that just upping my Vitamin D is allowing my body to shed some weight? At last? Remember (I find this hard to keep in mind) ... Vitamin D3 is not actually a vitamin. It's a hormone. Then why do they call it "Vitamin D" instead of "Hormone D"? I don't get it! Well now I do, because I looked it up and found it here. It seems that it was in the early 70's that scientists discovered that Vitamin D is a hormone and not a vitamin:
"One of the reasons vitamin D was a puzzle to scientists for so many years was that it was initially misidentified as a true vitamin, that is an essential substance that our bodies cannot manufacture and which therefore, can only be obtained from our food. But, unlike essential dietary trace elements, such as vitamins A, B, and C, which humans must get directly from food, vitamin D can be produced in the body through a photosynthetic reaction when the skin is exposed to sunlight. The resulting substance is only a precursor, however, which must then undergo two transformations--first in the liver and then in the kidney--to become the biologically active substance the body uses. This active form of vitamin D is a hormone, chemically akin to familiar steroid hormones, such as the sex regulators testosterone and estrogen and the stress regulator cortisol."
Whatever the reason for my recent miracle weight loss, I don't understand it and I'm afraid to get too excited! It's too bizarre! I just hope it continues for a while longer! I would so love to feel like my smaller self again! If I figure it out, I'll let you know. If you have any ideas, please share.

Just think ... if I start adding more exercise to the mix, at this rate I would be slimmish again before next fall! That would be too much to hope for. I know it.
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Monday, February 22, 2010

Vitamin D Registering Optimal

Day 4 of being back to work! Yeah! I'm glad yesterday wasn't a work day or I don't think I would have made it but today I felt good ... well rested after a long sleep. It was nice to see my colleagues who were away last week! It surprises me, though, how quickly I get tired. I was pretty tired when I left work this afternoon.

I picked up my Vitamin D test results (they take a long time) that I had done on January 20th, just before I started the high doses of Vitamin D (20,000 IU per day for one week, followed by 10,000 IU per day for three weeks) and after I had been taking 4,000 IU per day for a while ... I can't remember how long.

I'm happy to say that my Vitamin D levels have moved up into the bottom of the optimal range! That's good! My previous test showed levels of 74 nmol/L and now my levels are at 127 nmol/L.

I found the following chart in this Vitamin D Information Sheet (pdf). It generally reflects most of the guidelines I've seen, with only slight variations. I've put the "normal levels" from my Saskatchewan Health Region lab report in red.
  • Below 20 ng/ml (50 nmol/L) = deficient (below 25 nmol/L)
  • Below 30 ng/ml (75 nmol/L) = insufficient (25-70 nmol/L)
  • 30 – 60 ng/ml (75 - 150 nmol/L) considered sufficient (no listing)
  • 50 – 80 ng/ml (125 – 200 nmol/L) considered optimal by some groups (70-250 nmol/L)
  • Over 100 ng/ml (250 nmol/L) = excessive (no listing)
  • Over 150 ng/ml (380 nmol/L) = toxic (over 250 nmol/L)
This explains why my medical doctor told me that my 74 nmol/L was "normal", while my naturopathic doctor told me it indicated deficiency. My research leads me to strongly side with my naturopathic doctor and I marvel that my medical doctor didn't even encourage me to increase my Vitamin D intake to aim for something more optimal, considering I was at the very bottom of a rather broad range. Well, he wouldn't have tested my Vitamin D at all if I hadn't asked him on behalf of my naturopathic doctor. This experience (among others) reminds me of the importance of educating oneself and taking charge of one's own health. I also know now not to trust doctors to look out for my best interests. Well, not my doctor anyway. Maybe you have doctors who are more proactive and who believe in preventative medicine instead of just band-aid solutions. Note to self: get new doctor before I become even more jaded.

Kevin is still sick today. He spent the day on the couch probably sleeping more than anything. He's still sleeping.

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Sunday, February 21, 2010

New research about the joint/bone/muscle/tendon problems I've been having

Aromatase inhibitor-induced arthralgia in early breast cancer: what do we know and how can we find out more?
Breast Cancer Research and Treatment, Monday, February 16, 2010 (link)
Abstract: Aromatase inhibitors (AIs [such as Arimidex, which is what I took that caused my joint problems]) are a standard of care for the adjuvant treatment of hormone responsive early [breast cancer] ... Arthralgia was a somewhat unexpected side effect of this class of agents and has proven to be potentially problematic in clinical practice. Although rates of up 35% have been reported in the randomised trials, the figure has been much higher in subsequent case series. There is concern that these symptoms are significant and may affect compliance and thus the overall efficacy of treatment. It is therefore extremely important that we evaluate this syndrome with a view to gaining more information regarding its clinical features and possible aetiological mechanism. The potential aetiological mechanisms and evidence for aromatase inhibitor-induced arthralgia (AIA [the bone, joint, tendon and muscle problem I've experience]) are reviewed in this article. Looking forward, it is now important that prospective clinical trials are well designed to evaluate this syndrome and potential therapeutic strategies to circumvent it. Radiological imaging and biochemical analyses may help our understanding of AIA and these are discussed.
Great ... looks like they're just starting to really research this side effect that has caused me so much grief these last 4 months. No wonder I'm having trouble getting any useful answers.

In this research report released on the same day, the following statement is included in the abstract: " ... vitamin D is being investigated as a means to reduce aromatase inhibitor-induced joint symptoms." (link to study published in Current Oncology Reports.
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Prevention of Aromatase Inhibitor-Induced Bone Loss Using Risendronate: The SABRE Trial.
Journal of Clinical Oncology, Vol 28, No 6 (February 20), 2010: pp. 967-975 (link)
Conclusion: In postmenopausal women at risk of fragility fracture who were receiving adjuvant anastrozole [such as Arimidex, which is what I was taking that caused my joint and bone problems] for EBC [breast cancer], the addition of risedronate at doses established for preventing and treating osteoporosis resulted in favorable effects in BMD during 24 months.

Supported by AstraZeneca Pharmaceuticals [the company that makes Arimidex]
This means they're at least looking for ways to deal with the long term bone and joint problems that women using estrogen blockers (like Arimidex) are experiencing.

** Note that the text in square brackets are mine.
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